Both r SALO and SGH inhibited C4b deposition and cleavage of C4. longipalpis salivary gland homogenate (SGH)counterparts and anti-r SALO antibodies blocked the classical pathway complement activity of r SALO and SGH. r SALO anti-complement activity has the same chromatographic properties as the Lu. SALO, an 11 kDa protein, has no homology to proteins of any other organism apart from New World sand flies. Here, we identified SALO as the classical pathway complement inhibitor. Sand fly saliva was shown to inhibit the classical pathway of complement however, the molecular identity of the inhibitor remains unknown. SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis.įerreira, Viviana P Fazito Vale, Vladimir Pangburn, Michael K Abdeladhim, Maha Mendes-Sousa, Antonio Ferreira Coutinho-Abreu, Iliano V Rasouli, Manoochehr Brandt, Elizabeth A Meneses, Claudio Lima, Kolyvan Ferreira Nascimento Araújo, Ricardo Pereira, Marcos Horácio Kotsyfakis, Michalis Oliveira, Fabiano Kamhawi, Shaden Ribeiro, Jose M C Gontijo, Nelder F Collin, Nicolas Valenzuela, Jesus Gīlood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Soome ja Eesti uute lastelaulude konkursist Salos, kus parimaks lauluks osutus Külli Marandi "Pesapuu" Rahvusvahelisest laste laulufestivalist 5.-8.juunil Salos, kus esikoha võitis 11. Kose laulupoiss võitis rahvusvahelise lauluvõistluse Salos / Riin Kivinurm
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